PERBEDAAN BERMAKNA KADAR SERUM AMILOID A ANTARA STENOSIS KORONER DIBANDINGKAN BUKAN STENOSIS KORONER (Significantly Higher Level of Serum Amyloid A Among Coronary Stenosis Compared to NonStenosis)

I Nyoman G Sudana, Setyawati Setyawati, Usi Sukorini

Abstract


Coronary stenosis is one of the major causes of death from heart disease. The gold standard of coronary stenosis diagnosis is
established with angiography, however it is invasively, complicated and expensive. Serum Amyloid A (SAA) is an acute phase protein
that appears as chronic and acute inflammatory agent that is specific to the process of stenosis development. Serum Amyloidal A test
method is noninvasive, relatively easy and affordable. The aim of this study was to know the differences of Serum Amyloid A levels
in patients with nonstenosis and coronary stenosis in Dr. Sardjito General Hospital Yogyakarta by determination. The study is a case
control study. The samples were selected consecutively with typical chest pain, were divided into two (2) groups of nonstenosis and
stenosis by coronary angiography test. The principal of the Serum Amyloid A test is ELISA method. Nonstenosis and coronary stenosis
groups were analyzed by mean of Serum Amyloid A level based on the angiography test. The data were analyzed with Independent
t-test, odds ratio with a significancy of p <0.05 and confidence interval 95%. The samples of this study consisted of 60 patients, divided
into nonstenosis and coronary stenosis. The analysis of Independent t tests showed significant differences between the subject SAA levels
of nonstenosis and stenosis (4.35 ug/mL vs 21.75 mg/mL, p=0.001, with an odds ratio 9.84 (CI 95% 2.38 to 40.73). Based on this
study, it can be conclued that the results indicate significantly higher level of Amyloid A Serum among the coronary stenosis compared
to the nonstenosis.


Keywords


Serum Amyloid A, nonstenosis, coronary stenosis, angiography

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DOI: http://dx.doi.org/10.24293/ijcpml.v21i3.1273

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ACREDITED No. 36a/E/KPT/2016, 23 Mei 2016

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