FIBRINOGEN DAN TRANSCRANIAL DOPPLER DI STROK ISKEMIK AKUT (Fibrinogen and Transcranial Doppler in Acute Ischemic Stroke)

Hafizah Soraya Dalimunthe, Adi Koesoema Aman, Yuneldi Anwar

Abstract


Elevated fibrinogen levels is related to the blood hyperviscosity, that causes low blood velocity. Non-contrast-enhanced transcranial
Doppler (TCD) is used to evaluate blood flow from the cerebrovascular system. To know the relationship between fibrinogen levels and
examination of TCD in acute ischemic stroke through evaluation. A cross sectional study was admitted from July 2012-Juny 2013.
The researchers determined the differences between fibrinogen and TCD in the stroke group and control. The researchers examined
the relationship between fibrinogen and TCD examination in the stroke group. The fibrinogenwas measured with Clauss method. The
TCD was examined due to middle of the cerebral artery (MCA) and the Internal Carotid one Artery (ICA). The patients were diagnosed
as ischemic stroke from head CT-scan. Statistical analyses employed the Independent T test, Anova test and Pearson correlation. The
researchers had 24 patients and 24 controls that the Fibrinogen levels in stroke group is 549.16±104.84 mg/mL and in the control group
is 385.64±16.80 mg/mL. The researchers examined MCA in the stroke as well as the control and found the mean velocity 43.12±21.03
and 56.97±6.22 (p=0.05), the peak velocity 74.17±32.58 and 94.55±14.11 (p=0.05) end diastolic velocity 23.27±12.66 and
35.30±7.34 (p=0.00). In ICA, the stroke group and control and found the mean velocity 31.40±8.86 and 43.07±8.06 (p=0.00), the
peak velocity 54.99±11.50 and 75.04±16.04 (p=0.00) end diastolic velocity 18.23±7.67 and 25.64±5.24 (p=0.00). The correlation
between fibrinogen and TCD in the stroke group was not significant on MCA and ICA, P>0.05. It can be concluded that the differences
between fibrinogen levels and TCD in the stroke group and control are significant. But there is no correlation between the fibrinogen
and TCD in the stroke group.


Keywords


Fibrinogen, transcranial doppler, acute ischemic stroke

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DOI: http://dx.doi.org/10.24293/ijcpml.v21i3.1281

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ACREDITED No. 36a/E/KPT/2016, 23 Mei 2016

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